FB2024_01 , released February 22, 2024
Gene Group : CYTOSOLIC GLUTATHIONE S-TRANSFERASES
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General Information
Name
CYTOSOLIC GLUTATHIONE S-TRANSFERASES
Species
D. melanogaster
Symbol
GST-C
FlyBase ID
FBgg0000155
Date last reviewed
2022-09-06
Number of members
35
Description
Description
Glutathione transferases (glutathione S-transferases, GST) catalyze nucleophilic attack by reduced glutathione on nonpolar compounds that contain an electrophilic carbon, nitrogen, or sulfur atom. At least 14 classes of cytosolic GSTs have been identified in prokaryotes and eukaryotes: Theta, Omega, Sigma and Zeta exist in all eukaryotes. D. melanogaster has two additional classes, Delta and Epsilon. In D. mel, the class is indicated by the letter after the Gst prefix. (Adapted from FBrf0217315 and PMID:15822171).
Notes on Group

se is an Omega GST.

gfzf is atypical, the GST domain being part of a larger protein and is sometime excluded from analysis of GSTs. (FBrf0202224)

Gdap1 is not classed as a GST because it "belongs to a new group of GST-like proteins, quite different from all other GST classes...although it is likely that GDAP1-class proteins bind glutathione and perhaps function as glutathione transferases, the cellular context of their functions may be essentially different from those of canonical GSTs." (FBrf0212680).

gfzf is atypical, the GST domain being part of a larger protein and is sometime excluded from analysis of GSTs (FBrf0202224). gfzf has transcriptional coactivator activity and glutathione S-transferase activity and has been localised to the nucleus in some studies (FBrf0250640).

GstD3 and GstT4 are excluded from this group because they display no glutathione transferase activity for any substrate tested (FBrf0217315).

Source Material
The CYTOSOLIC GLUTATHIONE S-TRANSFERASES Gene Group has been compiled using the following publication(s): Gonis et al., 2022, Baumann et al., 2018, Wongtrakul et al., 2014, Saisawang et al., 2012, Low et al., 2007, and Marco et al., 2004 .
Key Gene Ontology (GO) terms
Cellular Component
Enzymatic activity
Enzyme name (EC)
glutathione transferase (2.5.1.18)
Related Gene Groups
Other related group(s)
Members (35)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
GST-containing FLYWCH zinc-finger protein
lethal (3) 84Cc, dGFZF, l(3)84Cc, Su(Kpn)
Glutathione S transferase D1
GST, gstD, DmGSTD1, DmGST1, GST-1
Glutathione S transferase D2
gstD21, DmGSTD2, DmGST21, Gst
Glutathione S transferase D4
DmGST23, DmGSTD4, Gst
Glutathione S transferase D5
DmGSTD5, DmGST24, Gst, GstD24
Glutathione S transferase D6
DmGSTD6, DmGST25, Gst
Glutathione S transferase D7
DmGSTD7, DmGST26, Gst
Glutathione S transferase D8
DmGST27, DmGSTD8, Gst, GstD27
Glutathione S transferase E1
Gst3, GST-3
Glutathione S transferase E8
Gst3-2, DmGSTE8
Glutathione S transferase E12
BcDNA:GH04753, GST
Glutathione S transferase S1
Gst2, GST-2, DmGSTS1-1, GST, DmGST2
External Data
Synonyms and Secondary IDs
Synonym(s)
GST-C
cytoplasmic glutathione S-transferases
soluble glutathione S-transferase
soluble GST
sGST
CYTOPLASMIC S-GLUTATHIONE TRANSFERASES
CYTOSOLIC GLUTATHIONE S-TRANSFERASES
Secondary FlyBase ID(s)
References (8)