FB2024_02 , released April 23, 2024
Gene Group : TRIM UBIQUITIN LIGASES
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General Information
Name
TRIM UBIQUITIN LIGASES
Species
D. melanogaster
Symbol
E3-TRIM
FlyBase ID
FBgg0000182
Date last reviewed
2014-07-10
Number of members
5
Description
Description
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. The TRIM family are E3 ligases characterized a TRIpartite Motif, which consists of a RING domain, one or two B-box motifs and a coiled-coil region. As well as ubiquitination, TRIM proteins are also involved in ubiquitin-like modifications such as SUMOylation and ISGylation. (Adapted from PMID:18673550).
Notes on Group

brat and wech are not included from FBrf0225008 in the TRIM UBIQUITIN LIGASES as they do not contain a RING domain.

The TRIM E3 ligases are also known as RBCC proteins, an acronym derived from the three motifs-RING, B-box and coiled-coil.

Source Material
The TRIM UBIQUITIN LIGASES Gene Group has been compiled using the following publication(s): Wisotzkey et al., 2014, Du et al., 2011, Ying et al., 2011, and Sardiello et al., 2008 .
Key Gene Ontology (GO) terms
Molecular Function
ubiquitin protein ligase activity
Biological Process
protein ubiquitination
Cellular Component
Related Gene Groups
Parent group(s)
RING DOMAIN E3 UBIQUITIN LIGASES
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
bon
bonus
(FlyBase, 2017-, Wisotzkey et al., 2014, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)
CG8419
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)
mei-P26
meiotic P26
BcDNA:GH10646
(FlyBase, 2017-, Wisotzkey et al., 2014, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)
tn
thin
abba, TRIM32, l(2)tn
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)
Trim9
Tripartite motif containing 9
dTrim9, asap
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
E3-TRIM
TRIM UBIQUITIN LIGASES
E3 ligase
Ubiquitin ligase
TRIM ubiquitin ligase
Tripartite motif containing E3 ligase
RBCC proteins
E3
TRIM
RBCC
Secondary FlyBase ID(s)
References (6)