FB2024_02 , released April 23, 2024
Gene Group : RETROMER
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General Information
Name
RETROMER
Species
D. melanogaster
Symbol
RETRO
FlyBase ID
FBgg0000196
Date last reviewed
2023-08-08
Number of members
6
Description
Description
The retromer coat complex is involved in the endosomal sorting of membrane proteins, particularly in the endosome-to-Golgi (retrograde) retrieval pathway. The complex can be divided into two subcomplexes, a cargo-selective trimer and a heterodimeric BAR-domain-containing sorting nexin complex that promotes formation of endosomal membrane tubules into which cargo proteins are sorted. (Adapted from PMID:23148298).
Notes on Group

The composition of the sorting nexin heterodimer may influence cargo selection. Snx1/Snx6 are thought of as the classical retromer complex sorting nexins. In D.mel, Snx3 is required for the endocytic recycling of wls (FBrf0216871).

Source Material
The RETROMER Gene Group has been compiled using the following publication(s): Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011, and Zhang et al., 2011 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
retrograde transport, endosome to Golgi
Cellular Component
retromer complex
endosome
Related Gene Groups
Parent group(s)
INTRACELLULAR TRANSPORT COAT, SCAFFOLD AND ADAPTOR PROTEINS
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Snx1
Sorting nexin 1
Vps5
(Li and Blissard, 2015, Koumandou et al., 2011, Koumandou et al., 2011, Zhang et al., 2011)
Snx3
Sorting nexin 3
lincRNA.S6645, Dsnx3
(Maruzs et al., 2015, Koumandou et al., 2011, Zhang et al., 2011)
Snx6
Sorting nexin 6
Dsnx6
(Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011, Zhang et al., 2011)
Vps26
Vacuolar protein sorting 26
EG:63B12.8, dvps26
(Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011)
Vps29
Vacuolar protein sorting 29
(Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011)
Vps35
Vacuolar protein sorting 35
dvps35
(Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011, Zhang et al., 2011)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RETRO
RETROMER
Retromer coat complex
Secondary FlyBase ID(s)
References (6)