FB2024_02 , released April 23, 2024
Gene Group : WAVE REGULATORY COMPLEX
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General Information
Name
WAVE REGULATORY COMPLEX
Species
D. melanogaster
Symbol
WRC
FlyBase ID
FBgg0000492
Date last reviewed
2022-11-02
Number of members
5
Description
Description
The WAVE Regulatory Complex (WRC) is a multi-subunit complex that controls actin cytoskeletal dynamics. WRC activates the Arp2/3-mediated actin nucleation. WRC contains the nucleation-promoting factor SCAR, a member of the WASP family. (Adapted from FBrf0208042 and FBrf0224564).
Notes on Group
Source Material
The WAVE REGULATORY COMPLEX Gene Group has been compiled using the following publication(s): Chen et al., 2014, Chia et al., 2014, Law et al., 2013, Fricke et al., 2009, and Ismail et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
actin cytoskeleton organization
Cellular Component
SCAR complex
Related Gene Groups
Other related group(s)
WISKOTT-ALDRICH SYNDROME PROTEINS
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Abi
Abelson interacting protein
dAbi, Abelson interactor, Ablphilin
(Chen et al., 2014, Chia et al., 2014, Law et al., 2013, Fricke et al., 2009, Ismail et al., 2009)
Cyfip
Cytoplasmic FMR1 interacting protein
Sra-1, Sra1, dSra, PIR121, DSra-1
(Chen et al., 2014, Chia et al., 2014, Law et al., 2013, Fricke et al., 2009, Ismail et al., 2009)
Hem
HEM-protein
kette, Nap1, kte, Kette/Nap1, dhem
(Chen et al., 2014, Chia et al., 2014, Law et al., 2013, Fricke et al., 2009, Ismail et al., 2009)
HSPC300
Haematopoietic stem/progenitor cell protein 300
dHSPC300
(Chen et al., 2014, Chia et al., 2014, Law et al., 2013, Fricke et al., 2009, Ismail et al., 2009)
SCAR
SCAR
WAVE, l(2)k03107, dWAVE, SCAR/WAVE, l(2)k13811
(Chen et al., 2014, Chia et al., 2014, Law et al., 2013, Fricke et al., 2009, Ismail et al., 2009)
External Data
Synonyms and Secondary IDs
Synonym(s)
WRC
WAVE
WAVE REGULATORY COMPLEX
WAVE complex
Scar/WAVE complex
SCAR complex
Secondary FlyBase ID(s)
References (6)