FB2024_02 , released April 23, 2024
FB2024_02 , released April 23, 2024
CV Term Report
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General Information
Term GTPase activity ID (Ontology) GO:0003924 (Gene Ontology)
Definition Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.[ PubMed:26832457 PubMed:27218782 ]
Comment
Links to Extrernal Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION     147
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 GTPase activity (all annotations which use CV term, excluding "NOT" statements)      18    147
     contributes_to | GTPase activity       --       1
     enables | GTPase activity       --     147
 NOT | enables | GTPase activity       --       2
Spanning Tree (Parents/Children)
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  pyrophosphatase activity
   |__ribonucleoside triphosphate phosphatase activity
       |__GTPase activity  165 rec.
           |__G protein activity 2 rec.
           |__GTPase motor activity
               |__membrane scission GTPase motor activity
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Is a ribonucleoside triphosphate phosphatase activity
Part of
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Synonyms
  • "ARF small monomeric GTPase activity" NARROW
    "dynamin GTPase activity" NARROW
    "GTPase activity, coupled" RELATED
    "heterotrimeric G-protein GTPase activity" NARROW
    "heterotrimeric G-protein GTPase, alpha-subunit" RELATED
    "heterotrimeric G-protein GTPase, beta-subunit" RELATED
    "heterotrimeric G-protein GTPase, gamma-subunit" RELATED
    "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD
    "protein-synthesizing GTPase activity" NARROW
    "protein-synthesizing GTPase activity, elongation" NARROW
    "protein-synthesizing GTPase activity, initiation" NARROW
    "protein-synthesizing GTPase activity, termination" NARROW
    "Rab small monomeric GTPase activity" NARROW
    "Ran small monomeric GTPase activity" NARROW
    "Ras small monomeric GTPase activity" NARROW
    "RHEB small monomeric GTPase activity" NARROW
    "Rho small monomeric GTPase activity" NARROW
    "Sar small monomeric GTPase activity" NARROW
    "signal-recognition-particle GTPase activity" NARROW
    "small monomeric GTPase activity" NARROW
    "tubulin GTPase activity" NARROW
Secondary IDs
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MetaCyc:RXN0-5462
Reactome:R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP"
Reactome:R-HSA-1458485 "RALA hydrolyzes GTP"
Reactome:R-HSA-156923 "Hydrolysis of eEF1A:GTP"
Reactome:R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP"
Reactome:R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP"
Reactome:R-HSA-167415 "G-protein alpha subunit is inactivated"
Reactome:R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf"
Reactome:R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf"
Reactome:R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha"
Reactome:R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle"
Reactome:R-HSA-203973 "Vesicle budding"
Reactome:R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome"
Reactome:R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle"
Reactome:R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP"
Reactome:R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP"
Reactome:R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP"
Reactome:R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP"
Reactome:R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP"
Reactome:R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP"
Reactome:R-HSA-421835 "trans-Golgi Network Vesicle Scission"
Reactome:R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha"
Reactome:R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission"
Reactome:R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC"
Reactome:R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA"
Reactome:R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome"
Reactome:R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits"
Reactome:R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)"
Reactome:R-HSA-555065 "Formation of clathrin coated vesicle"
Reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4"
Reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP"
Reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity"
Reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments"
Reactome:R-HSA-5672017 "Rheb in the MTORC1 complex hydrolyses GTP"
Reactome:R-HSA-5694527 "Loss of SAR1B GTPase"
Reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity"
Reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP"
Reactome:R-HSA-8847534 "RAB43 hydrolyses GTP"
Reactome:R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity"
Reactome:R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity"
Reactome:R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35"
Reactome:R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7"
Reactome:R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7"
Reactome:R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A"
Reactome:R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B"
Reactome:R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission"
Reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity"
Reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated"
Reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated"
Reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated"
Reactome:R-HSA-9018814 "RHOT1 hydrolyzes GTP"
Reactome:R-HSA-9018826 "RHOT2 hydrolyzes GTP"
Reactome:R-HSA-9640195 "RRAGA,B hydrolyzes GTP"
Reactome:R-HSA-9645598 "RRAGC,D hydrolyzes GTP"
Reactome:R-HSA-9649736 "RAS intrinsic GTPase activity hydrolyzes GTP to GDP"
Reactome:R-HSA-983422 "Disassembly of COPII coated vesicle"
RHEA:19669