FB2024_02 , released April 23, 2024
FB2024_02 , released April 23, 2024
CV Term Report
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General Information
Term glutathione transferase activity ID (Ontology) GO:0004364 (Gene Ontology)
Definition Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.[ EC:2 ]
Also Known As "glutathione conjugation reaction"
Comment
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      38
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 Gene Groups Genes
 glutathione transferase activity (all annotations which use CV term, excluding "NOT" statements)       3     38
     enables | glutathione transferase activity       --      38
 NOT | enables | glutathione transferase activity       --       2
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  transferase activity
   |__transferase activity, transferring alkyl or aryl (other than methyl) groups
       |__glutathione transferase activity  41 rec.
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Is a transferase activity, transferring alkyl or aryl (other than methyl) groups
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Synonyms
  • "glutathione conjugation reaction" EXACT
    "glutathione S-alkyl transferase activity" RELATED[ EC:2 ]
    "glutathione S-alkyltransferase activity" RELATED[ EC:2 ]
    "glutathione S-aralkyltransferase activity" RELATED[ EC:2 ]
    "glutathione S-aryltransferase activity" RELATED[ EC:2 ]
    "glutathione S-transferase activity" RELATED[ EC:2 ]
    "RX:glutathione R-transferase activity" RELATED[ EC:2 ]
    "S-(hydroxyalkyl)glutathione lyase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.5.1.18
MetaCyc:GSHTRAN-RXN
Reactome:R-HSA-176054 "GST dimers conjugate GSH with cytosolic substrates"
Reactome:R-HSA-176059 "GST trimers transfer GS from GSH to luminal substrates"
Reactome:R-HSA-3301943 "GSTK1 dimer transfers GS from GSH to CDNB"
Reactome:R-HSA-5423653 "MGST trimers transfer GS from GSH to AFXBO and AFNBO"
Reactome:R-HSA-9026777 "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1"
Reactome:R-HSA-9026780 "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1"
Reactome:R-HSA-9026901 "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1"
Reactome:R-HSA-9026911 "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1"
Reactome:R-HSA-9748996 "GST dimers cleave AZA to 6MP"
Reactome:R-HSA-9753280 "GSTs transfer GSH to NAPQI to form APAP-SG"