FB2024_02 , released April 23, 2024
FB2024_02 , released April 23, 2024
CV Term Report
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General Information
Term cysteine-type deubiquitinase activity ID (Ontology) GO:0004843 (Gene Ontology)
Definition An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.[ PubMed:30783221 ]
Also Known As "thiol-dependent deubiquitinase" ; "thiol-dependent ubiquitin-specific protease activity" ; "thiol-dependent ubiquitinyl hydrolase activity"
Comment
Links to Extrernal Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      36
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 cysteine-type deubiquitinase activity (all annotations which use CV term, excluding "NOT" statements)      10     36
     enables | cysteine-type deubiquitinase activity       --      36
 NOT | enables | cysteine-type deubiquitinase activity       --       4
Spanning Tree (Parents/Children)
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peptidase activity
 |__cysteine-type peptidase activity_______
ubiquitin-like protein peptidase activity  |
 |__deubiquitinase activity________________|
                                           cysteine-type deubiquitinase activity  46 rec.
                                            |__Met1-linked polyubiquitin deubiquitinase activity 1 rec.
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Is a cysteine-type peptidase activity
deubiquitinase activity
Part of
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Synonyms
  • "deubiquitinase" BROAD[ PubMed:19261746 ]
    "deubiquitinase activity" BROAD
    "deubiquitinating enzyme" BROAD[ PubMed:19188440 ]
    "deubiquitylase" BROAD[ PubMed:15657442 ]
    "thiol-dependent deubiquitinase" EXACT
    "thiol-dependent ubiquitin-specific protease activity" EXACT
    "thiol-dependent ubiquitinyl hydrolase activity" EXACT
    "ubiquitin C-terminal hydrolase" RELATED[ EC:3 ]
    "ubiquitin hydrolase activity" BROAD
    "ubiquitin-specific protease activity" BROAD
    "ubiquitinyl hydrolase 1 activity" NARROW
    "ubiquitinyl hydrolase activity" BROAD
    "UBP" NARROW
    "UCH2" NARROW
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.4.19.12
Reactome:R-HSA-1358795 "Deubiquitination of RNF41 by P-USP8"
Reactome:R-HSA-2179291 "UCHL5, USP15 deubiquitinate TGFBR1"
Reactome:R-HSA-3215295 "USP7 deubiquitinates MDM2"
Reactome:R-HSA-3215310 "USP7 deubiquitinates TP53 and counteracts MDM2"
Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2"
Reactome:R-HSA-4641236 "USP8 deubiquitinates FZD to potentiate WNT signaling"
Reactome:R-HSA-5653770 "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA"
Reactome:R-HSA-5655466 "USP1:WDR48 deubiquitinates monoUb:K164-PCNA"
Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains"
Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2"
Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN"
Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4"
Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53"
Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B"
Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin"
Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A"
Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58"
Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128"
Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts"
Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1"
Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex"
Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A"
Reactome:R-HSA-5696465 "USP45 deubiquitinates ERCC1"
Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1"
Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58"
Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1"
Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR"
Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG"
Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins"
Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC"
Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB"
Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB"
Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20"
Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B"
Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2"
Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2"
Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2"
Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1"
Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10"
Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123"
Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA"
Reactome:R-HSA-6782069 "UVSSA:USP7 deubiquitinates ERCC6"
Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR"
Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS"
Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3"
Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33"
Reactome:R-HSA-6786171 "FANCD2 deubiquitination by USP1:WDR48"
Reactome:R-HSA-6807118 "USP7 deubiquitinates monoubiquitinated PTEN"
Reactome:R-HSA-6807206 "USP13 and OTUD3 deubiquitinate PTEN"
Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4"
Reactome:R-HSA-8853503 "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin"
Reactome:R-HSA-8853514 "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin"
Reactome:R-HSA-8853515 "OTULIN,USP5 cleaves UBC yielding ubiquitin"
Reactome:R-HSA-8853529 "OTULIN,USP5 cleaves UBB yielding ubiquitin"
Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin"
Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb"
Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6"
Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN"
Reactome:R-HSA-8875443 "USP8 deubiquitinates LRIG1"
Reactome:R-HSA-8986083 "USP33 deubiquitinates ROBO1"
Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin"
Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin"
Reactome:R-HSA-9653514 "USP17L2 deubiquitinates RCE1"