FB2024_02 , released April 23, 2024
FB2024_02 , released April 23, 2024
CV Term Report
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General Information
Term ubiquitin protein ligase activity ID (Ontology) GO:0061630 (Gene Ontology)
Definition Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.[ PubMed:22863777 ]
Also Known As "protein ubiquitination activity" ; "ubiquitin ligase activity"
Comment
Links to Extrernal Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION     148
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 ubiquitin protein ligase activity (all annotations which use CV term, excluding "NOT" statements)      17    148
     contributes_to | ubiquitin protein ligase activity       --       1
     enables | ubiquitin protein ligase activity       --     148
Spanning Tree (Parents/Children)
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ubiquitin-like protein transferase activity
 |__ubiquitin-protein transferase activity__
 |__ubiquitin-like protein ligase activity__|
                                            ubiquitin protein ligase activity  170 rec.
                                             |__histone ubiquitin ligase activity 3 rec.
                                             |   |__histone H2A ubiquitin ligase activity(+) 2 rec.
                                             |   |__histone H2B ubiquitin ligase activity(+) 1 rec.
                                             |   |__histone H3 ubiquitin ligase activity(+)
                                             |   |__histone H4 ubiquitin ligase activity(+)
                                             |__ubiquitin-ubiquitin ligase activity 5 rec.
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Is a ubiquitin-protein transferase activity
ubiquitin-like protein ligase activity
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Synonyms
  • "E3" BROAD
    "ER-associated E3 ligase" RELATED[ PubMed:24019521 ]
    "protein ubiquitination activity" EXACT
    "ubiquitin ligase activity" EXACT
Secondary IDs
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Reactome:R-HSA-1225956 "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL"
Reactome:R-HSA-1504190 "DVL is ubiquitinated by CUL3:KLHL12:RBX1"
Reactome:R-HSA-201445 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8"
Reactome:R-HSA-3322429 "XIAP monoubiquinates TLE"
Reactome:R-HSA-3640861 "RNF146 ubiquitinates ADP-ribosylated AXIN"
Reactome:R-HSA-4608852 "SMURF1/2 ubiquitinates PRICKLE1"
Reactome:R-HSA-4641129 "AXIN is ubiquitinated by SMURF2"
Reactome:R-HSA-4641159 "DVL1 is ubiquitinated by HECW1"
Reactome:R-HSA-4641246 "ZNRF3 autoubiquitinates to promote its internalization"
Reactome:R-HSA-4641253 "ZNRF3 ubiquitinates FZD to promote its downregulation"
Reactome:R-HSA-5246693 "APC is K63-polyubiquitinated"
Reactome:R-HSA-5610737 "NUMB:ITCH bind and ubiquitnate GLI1"
Reactome:R-HSA-5632648 "SMURF1/2 ubiquitinates PTCH1"
Reactome:R-HSA-5635856 "SPOP:CUL3:RBX1 ubiquitinates GLI2,3"
Reactome:R-HSA-5635864 "NUMB:ITCH ubiquitinates GLI1"
Reactome:R-HSA-5654672 "CBL ubiquitinates FRS2 and FGFR1"
Reactome:R-HSA-5654677 "CBL ubiquitinates FRS2 and FGFR2"
Reactome:R-HSA-5654679 "CBL ubiquitinates FRS2 and FGFR3"
Reactome:R-HSA-5654684 "CBL ubiquitinates FRS2 and FGFR4"
Reactome:R-HSA-5658424 "KBTBD7:CUL3:RBX1 ubiquitinates NF1"
Reactome:R-HSA-5674022 "BRAP autoubiquitinates"
Reactome:R-HSA-5682858 "RNF8 and RNF168 ubiquitinate H2AFX"
Reactome:R-HSA-5684071 "RNF4 ubiquitinates MDC1"
Reactome:R-HSA-5687081 "MAPK6 is ubiquitinated at the N-terminal"
Reactome:R-HSA-5689111 "PARK2 autoubiquitinates"
Reactome:R-HSA-5690827 "TNFAIP3 (A20) ubiquitinates RIPK1"
Reactome:R-HSA-6781867 "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II"
Reactome:R-HSA-6782943 "UV-DDB ubiquitinates XPC"
Reactome:R-HSA-6785361 "Monoubiquitination of FANCD2:FANCI"
Reactome:R-HSA-6790487 "RNF111 ubiquitinates SUMOylated XPC"
Reactome:R-HSA-6798373 "MDM2 ubiquitinates DYRK2"
Reactome:R-HSA-6804253 "MDM2 ubiquitinates JMY"
Reactome:R-HSA-6804441 "RNF34 or RFFL ubiquitinates phosphorylated TP53"
Reactome:R-HSA-6804724 "MDM2 ubiquitinates phosphorylated MDM4"
Reactome:R-HSA-6804879 "MDM2 ubiquitinates TP53"
Reactome:R-HSA-6804942 "MDM2 homodimers auto-ubiquitinate"
Reactome:R-HSA-6807106 "PTEN undergoes monoubiquitination"
Reactome:R-HSA-6807134 "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN"
Reactome:R-HSA-68946 "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin"
Reactome:R-HSA-69015 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex"
Reactome:R-HSA-8848829 "CBL autoubiquitinates"
Reactome:R-HSA-8851011 "TRIM27 polyubiquitinates PTEN"
Reactome:R-HSA-8854041 "SCF-FBXL7 ubiquitinates AURKA"
Reactome:R-HSA-8854051 "SCF-FBXL18 ubiquitinates FBXL7"
Reactome:R-HSA-8854628 "MYLIP dimer ubiquitinates VLDLR on Lys-839"
Reactome:R-HSA-8866546 "RNF5 and RNF185 ubiquitinate misfolded CFTR"
Reactome:R-HSA-8866856 "RNF5 and RNF185 ubiquitinate CFTR F508del"
Reactome:R-HSA-8867288 "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5"
Reactome:R-HSA-8875183 "CBL monoubiquitinates activated MET"
Reactome:R-HSA-8875431 "LRIG1 undergoes ubiquitination"
Reactome:R-HSA-8876258 "CBL monoubiquitinates InlB-bound MET"
Reactome:R-HSA-8877003 "CBLL1 ubiqutinates the InlA-bound CDH1 complex"
Reactome:R-HSA-8938773 "RNF144A polyubiquitinates PRKDC"
Reactome:R-HSA-8938815 "RNF152 polyubiquitinates RRAGA"
Reactome:R-HSA-8939335 "RNF181 polyubiquinates BCL10"
Reactome:R-HSA-8939706 "SCF(SKP2) polyubiquitinates RUNX2"
Reactome:R-HSA-8942101 "RNF20:RNF40 monoubiquitinates Histone H2B"
Reactome:R-HSA-8943003 "SHPRH polyubiquitinates monoubiquitinated PCNA"
Reactome:R-HSA-8943040 "HLTF polyubiquitinates monoubiquitinated PCNA"
Reactome:R-HSA-8943080 "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11"
Reactome:R-HSA-8948775 "MKRN1 polyubiquitinates PTEN"
Reactome:R-HSA-8948832 "RNF146 polyubiquitinates PARylated PTEN"
Reactome:R-HSA-8952382 "MDM2 polyubiquitinates RUNX3"
Reactome:R-HSA-8952419 "SMURFs ubiquitinate RUNX3"
Reactome:R-HSA-8953946 "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11"
Reactome:R-HSA-8956026 "CUL9:RBX1 ubiquitinates BIRC5"
Reactome:R-HSA-8956684 "ITCH polyubiquitinates TP73"
Reactome:R-HSA-9008076 "WWP1 polyubiquitinates RUNX2"
Reactome:R-HSA-9008479 "FBXW7 polyubiquitinates RUNX2"
Reactome:R-HSA-9009308 "STUB1 polyubiquitinates RUNX2"
Reactome:R-HSA-9009403 "SMURF1 polyubiquitinates RUNX2"
Reactome:R-HSA-9011300 "ZSWIM8 ubiquitinates ROBO3.1"
Reactome:R-HSA-9021523 "WWP2 ubiquitinates NOTCH3"
Reactome:R-HSA-9033485 "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11"
Reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL"
Reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation"
Reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216"
Reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4"
Reactome:R-HSA-9685195 "SARS-CoV-1 9b recruits ITCH to MAVS"
Reactome:R-HSA-9686920 "PELI1 ubiquitinates RIPK3 at K363"
Reactome:R-HSA-9686969 "APC/C:Cdh1 polyubiquitinates SKP2"
Reactome:R-HSA-9705738 "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7"
Reactome:R-HSA-9706354 "Ubiquitination of FLT3"
Reactome:R-HSA-9706356 "CBL mutants don't ubiquitinate FLT3"
Reactome:R-HSA-9708517 "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))"
Reactome:R-HSA-9733316 "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL"
Reactome:R-HSA-9755304 "MUL1 ubiquitinates UBXN7"
Reactome:R-HSA-9755505 "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2"
Reactome:R-HSA-9759154 "TRIM21 ubiquitinates SQSTM1"
Reactome:R-HSA-9759172 "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer"
Reactome:R-HSA-9762091 "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1"
Reactome:R-HSA-9766645 "CUL3:RBX1 ubiquitinates KEAP1"
Reactome:R-HSA-990526 "Recruitment of ITCH and K48 ubiquitination of MAVS"