FB2024_02 , released April 23, 2024
Gene: Dmel\Deaf1
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General Information
Symbol
Dmel\Deaf1
Species
D. melanogaster
Name
Deformed epidermal autoregulatory factor-1
Annotation Symbol
CG8567
Feature Type
protein_coding_gene
FlyBase ID
FBgn0013799
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Transcription factor that binds the homeotic Deformed (Dfd) response element. High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences. May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein. Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd. (UniProt, Q24180)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

DEAF-1

Key Links
Genomic Location
Cytogenetic map
76D1-76D1
Sequence location
Recombination map
3-46
RefSeq locus
NT_037436 REGION:19818174..19830686
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from direct assay
(Reed et al., 2008)
enables sequence-specific DNA binding
inferred from direct assay
(Gross and McGinnis, 1996)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR000770
(InterPro Project Members, 2004-)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000812953
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in embryo development ending in birth or egg hatching
inferred from mutant phenotype
(Veraksa et al., 2002)
involved_in positive regulation of DNA-templated transcription
inferred from direct assay
(Gross and McGinnis, 1996)
involved_in regulation of immune response
inferred from direct assay
(Reed et al., 2008)
involved_in regulation of transcription by RNA polymerase II
inferred from direct assay
(Reed et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000812953
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Gross and McGinnis, 1996)
located_in polytene chromosome
inferred from direct assay
(Veraksa et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000812953
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
UNCLASSIFIED DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
This group comprises DNA-binding transcription factors that do not classify under other domain-based transcription factor groups in FlyBase.
Protein Function (UniProtKB)
Transcription factor that binds the homeotic Deformed (Dfd) response element. High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences. May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein. Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd.
(UniProt, Q24180)
Summary (Interactive Fly)

SAND and zf-MYND domain transcription factor - involved in embryonic development, Deformed autoregulation and the immune response

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Deaf1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24180)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.43

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Deaf1-RA
FBtr0074882
NM_079445
2425
576
Deaf1-RB
FBtr0100666
NM_001038944
2416
573
Deaf1-RC
FBtr0310476
NM_001275139
2042
539
Deaf1-RD
FBtr0332153
NM_001275140
3588
576
Deaf1-RE
FBtr0332726
NM_001275141
2033
536
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Deaf1-PA
FBpp0074651
61.6
576
6.32
Q24180
NP_524169
AAF49105
Deaf1-PB
FBpp0100128
61.3
573
6.40
Q86LC7
NP_001034033
ABC66130
Deaf1-PC
FBpp0302624
57.3
539
6.39
E8NH34
NP_001262068
AGB94761
Deaf1-PD
FBpp0304463
61.6
576
6.32
Q24180
NP_001262069
AGB94762
Deaf1-PE
FBpp0304972
57.0
536
6.50
M9PFP9
NP_001262070
AGB94763
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

576 aa isoforms: Deaf1-PA, Deaf1-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

576 (aa); 85 (kD observed)

(Gross and McGinnis, 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Deaf1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Gross and McGinnis, 1996)
embryonic stage 1 -- 17
organism | ubiquitous
• nucleus
(Gross and McGinnis, 1996)
embryonic stage 13
organism | ubiquitous
• nucleus
(Veraksa et al., 2002)
embryonic stage 15 -- 17
embryonic/larval central nervous system | intense
• nucleus
(Gross and McGinnis, 1996)
embryonic stage 16 -- 17
presumptive embryonic/larval nervous system
(Gross and McGinnis, 1996)
Additional Descriptive Data

Ubiquitous nuclear staining of Deaf1 protein was observed throughout most of embryogenesis. After stage 15, staining becomes more prominent in the CNS.

(Gross and McGinnis, 1996)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Gross and McGinnis, 1996)
located_in polytene chromosome
inferred from direct assay
(Veraksa et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Deaf1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Deaf1
Transgenic constructs containing regulatory region of Deaf1
Aberrations (Deficiencies and Duplications) ( 27 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Bx-MS1096
lethal | cold sensitive, with Scer\GAL4Bx-MS1096
lethal | larval stage, with Scer\GAL469B
lethal | larval stage, with Scer\GAL4arm.PS
lethal | pupal stage, with Scer\GAL469B
lethal | pupal stage, with Scer\GAL4arm.PS
lethal - all die before end of pupal stage | recessive
lethal - all die during embryonic stage | non-rescuable maternal effect
partially lethal, with Scer\GAL4Bx-MS1096
partially lethal, with Scer\GAL4dpp.blk1
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal eye color, with Scer\GAL4hs.2sev
some die during embryonic stage | non-rescuable maternal effect
some die during pupal stage | recessive
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4hs.2sev
Phenotype manifest in
Allele
embryo | dorsal closure stage | heat sensitive, with Scer\GAL4arm.PS
embryonic segment | non-rescuable maternal effect
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4hs.2sev
macrochaeta, with Scer\GAL4Bx-MS1096
mesothoracic bristle, with Scer\GAL4dpp.blk1
mitotic domain 1 | extended germ band stage | heat sensitive, with Scer\GAL4arm.PS
ommatidium, with Scer\GAL4GMR.PF
scutellar bristle, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing vein L3, with Scer\GAL4dpp.blk1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\DEAF1
9 of 14
Yes
Yes
Hsap\GMEB1
1 of 14
No
Yes
Hsap\GMEB2
1 of 14
No
Yes
Hsap\SAMD11
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Deaf1
10 of 14
Yes
Yes
Rnor\Gmeb2
1 of 14
No
Yes
Rnor\Samd11
1 of 14
No
No
Mus musculus (laboratory mouse) (4)
Mmus\Deaf1
9 of 14
Yes
Yes
Mmus\Gmeb1
1 of 14
No
Yes
Mmus\Gmeb2
1 of 14
No
Yes
Mmus\Samd11
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\deaf1
8 of 13
Yes
Yes
Xtro\eya1
1 of 13
No
No
Xtro\mknk2
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\deaf1
10 of 14
Yes
Yes
Drer\gmeb1
1 of 14
No
Yes
Drer\gmeb2
1 of 14
No
Yes
Drer\samd11
1 of 14
No
No
Drer\sp100.3
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\gmeb-1
2 of 14
Yes
Yes
Cele\gmeb-2
2 of 14
Yes
Yes
Cele\gmeb-3
2 of 14
Yes
Yes
Cele\spe-44
2 of 14
Yes
Yes
Cele\set-14
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP004905
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Deaf1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (2)
RAF2
1 of 13
Samuel
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    DEAF1; DEAF1 transcription factor
    model of  Vulto-van Silfout-de Vries syndrome
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DEAF1; DEAF1 transcription factor
    9 of 14
    602635
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Deaf1
    bimolecular fluorescence complementation, fluorescence microscopy, two hybrid array
    (Shokri et al., 2019)
    Deaf1 - Ada2b
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Weake et al., 2011)
    Deaf1 - Atf-2
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - Boh2
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - CG1233
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - CG13287
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - CG14535
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - CG30060
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - CG31955
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - CG32440
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - CG32713
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - CG32767
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - CG33223
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - CG33695
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - CG44247
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - CG4766
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - Camta
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - Clamp
    two hybrid, two hybrid array
    (Shokri et al., 2019, Hu et al., 2017.6.13)
    Deaf1 - Dpy-30L2
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - Ets65A
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - Grx5
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - Hr78
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - Ing3
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - MED19
    anti tag coimmunoprecipitation, anti tag western blot, two hybrid
    (Tang et al., 2023, Hu et al., 2017.6.13)
    Deaf1 - Mcm10
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - NFAT
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - PolZ2
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - Poxm
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - Poxn
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - Rel
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - SmB
    two hybrid, anti tag coimmunoprecipitation, anti tag western blot
    (Tang et al., 2023, Hu et al., 2017.6.13)
    Deaf1 - Spf45
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - Tektin-A
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - Ubx
    bimolecular fluorescence complementation, fluorescence microscopy
    (Bischof et al., 2018)
    Deaf1 - Unc-115a
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - abd-A
    bimolecular fluorescence complementation, fluorescence microscopy
    (Bischof et al., 2018)
    Deaf1 - bap
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - cactin
    anti tag coimmunoprecipitation, anti tag western blot
    (Zhang et al., 2020)
    Deaf1 - chn
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - glo
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - mtgo
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - ovo
    two hybrid array
    (Shokri et al., 2019)
    Deaf1 - ppl
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - ssh
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - term
    two hybrid
    (Hu et al., 2017.6.13)
    Deaf1 - ttk
    two hybrid array, bimolecular fluorescence complementation, fluorescence microscopy
    (Shokri et al., 2019)
    Deaf1 - tup
    two hybrid array
    (Shokri et al., 2019)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-46
    Cytogenetic map
    76D1-76D1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    76D1-76D1
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    76C-76D
    (Gross, 1996.1.19)
    76C-76C
    (determined by in situ hybridisation)
    (Gross and McGinnis, 1996)
    76C-76C
    (Veraksa and McGinnis, 1996)
    Experimentally Determined Recombination Data
    Location

    3-46

    (FlyBase, 2016)

    3-43.2

    (Comeron et al., 2012)

    3-

    (Gross, 1996.1.19)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (13)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (70)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Module E, a 120bp fragment of the Dfd epidermal autoregulatory element, contains a 51bp region, called 5-6, that is required to generate a functional Dfd response element, Dfd RE. Deaf1 acts through Module E in embryos and may function on other Dfd REs also.

        (Gross and McGinnis, 1996)

        The Deaf1 protein binds specifically to sequences found in a number of Dfd-dependent regulatory elements.

        (Gross and McGinnis, 1995)
        Relationship to Other Genes
        Source for database merge of
        Additional comments
        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (10)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 52 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (81)